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STX-1, a first-in-class ADC targeting DPP4 protein, acts as an anticancer andsenolytic treatment
Author Block: Benjamin Le Calvé, Delphine Dayde, Grégoire Jouffroy, Omayma Asbai, Virginie Lelarge, Justine Choeur, Thierry Mathieu, Florence Lhospice and Eric Angevin Starkage Therapeutics, Lille, France, Gustave Roussy, Villejuif, France Download PDF by clicking the image Abstract: Antibody-drug conjugates (ADCs) are innovative cancer therapies which, unlike conventional chemotherapies, enhance the anti-tumor effect while limiting adverse effects. However, it is necessary t

StarkAge
Jul 312 min read


Treatment-induced senescence in metastatic colorectal adenocarcinomas: implications for single-cell biology and therapeutic intervention.
Author Block: Antoine Hollebecque, Marine Aglave, Mohamed-Amine Bani, Trang Nguyen, Ludovic Bigot, Thierry Mathieu, Florence Lhospice, Benjamin Le Calvé, Eric Angevin Gustave Roussy, Villejuif, France, Starkage Therapeutics, Lille, France Download PDF HD by clicking the image Abstract: In cancers, the harmful effect of senescence is now well recognized and mediated by the local production of pro-inflammatory cytokines, soluble immunosuppressive factors and metalloproteinases

StarkAge
Jul 312 min read
StarkAge Therapeutics announces research collaboration with Gustave Roussy to advance senolytic therapies in digestive cancers
The collaboration will inform patient selection for treatment with STX-1, a first-in-class senolytic ADC directed against dipeptidyl-peptidase 4 (DPP4/CD26) as it progresses toward IND-enabling studies. Lille, France, January 27th, 2025 – StarkAge Therapeutics, a biotechnology company developing first-in-class senolytic antibody-drug conjugates (ADC) in age-related diseases, with an initial focus on oncology, today announced a research collaboration with Gustave Roussy, Europ

StarkAge
Jul 313 min read
New preclinical data on STX-1, a first-in-class senolytic ADC, to be presented at AACR 2026
Presentations highlight therapy-induced senescence as a new therapeutic opportunity and reinforce the potential of STX-1 as a differentiated approach for solid tumors Lille and Villejuif, France, April 16, 2026 – StarkAge Therapeutics, a biotechnology company pioneering first-in-class senolytic antibody-drug conjugates (ADC) for age-related diseases with an initial focus on oncology, today announced that it will present two posters at the AACR Annual Meeting 2026. These data

StarkAge
Apr 162 min read
StarkAge Therapeutics strengthens leadership with appointment of Dr. Florence Lhospice as Executive President and Dr. Éric Angevin as Chief Medical Officer
• Reinforcing StarkAge’s transition toward IND-enabling and early clinical development for STX-1 • Florence Lhospice, PharmD, PhD, brings ADC and CMC expertise as well as a strategic leadership to advance Starkage pipeline • Eric Angevin, MD, PhD, seasoned early-development oncologist, adds rare, direct clinical expertise in DPP4-targeted therapies Lille, France – December 4, 2025 – StarkAge Therapeutics, a biotechnology company developing first-in-class senolytic antibody-dr

StarkAge
Dec 4, 20253 min read
StarkAge Therapeutics lève 1,2 M€ pour accélérer le développementde sa thérapie ciblée STX-1 contre les cellules sénescentesinduites par les traitements anticancéreux
Lille, le 29 mai 2024. StarkAge Therapeutics, société de biotechnologie, annonce aujourd’hui une levée de fonds de 1,2 millions d’euros menée auprès de business angels, notamment des entrepreneurs en santé et de la BPI. La société, créée en 2018, est positionnée sur la recherche et le développement de thérapies dans le domaine de la senescence cellulaire avec pour objectif de lutter contre ses effets néfastes dans diverses maladies liées au vieillissement notamment les pathol

StarkAge
May 29, 20243 min read
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